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Some programs incorporate prescription medications when appropriate, including GLP-1 agonists, phentermine, or other weight loss drugs

The body has no reason to build or maintain muscle if no demand is being placed on it, regardless of how much raw material is available

Adults with biopsy-proven MASH and fibrosis stage F1F2F3, with or without type 2 diabetes, and with MRI-PDFF 8% at screening are randomised 1:1:1:1 to efocipegtrutide 2, 4, and 6 mg once-weekly subcutaneously or placebo for 52 weeks (estimated enrolment: N = 240)