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The glucagon component can transiently raise blood glucose before the GLP-1 and GIP components bring it back down

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10 The present study adopted the same modeling perspective and population structure but introduced the following 3 predefined modifications to better reflect realistic long-term obesity management pathways: Retreatment module: A new module was incorporated to allow the assessment of clinical and economic outcomes associated with re-initiating semaglutide following treatment discontinuation