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By influencing host epigenetics, activating G protein-coupled receptors, and preventing pathogenic microbial infections, SCFAs function as vital mediators between the gut microbiota and the host, acting as energy substrates for intestinal epithelial cells and preserving homeostasis in host immune and energy metabolism (119)

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By modulating ribF expression through mutations in its ribosome binding site and optimizing fermentation conditions, riboflavin production was improved by 12-fold up to a yield of 2702.8 mg/L in E