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Clinical data from both the STEP and SURMOUNT trials shows that GI side effects are concentrated during dose escalation and resolve for most participants within 4-8 weeks at any given dose level

& Keating, D

Tirzepatide (Mounjaro/Zepbound) could be a game-changer for weight loss and diabetesbut with prices exceeding $1,000 a month, is it even affordable

Common side effects during titration include: Nausea (most common, usually improves over time) Decreased appetite Diarrhea or constipation Injection site reactions Fatigue during initial dose adjustments Timeline for Testosterone Changes Men should not expect immediate testosterone improvements from tirzepatide alone