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doi: 10.1007/s10815-020-01973-6 16 KalehoeiEMojtabaMMehriAHosseinZSamanehALAHamidMet al

Because the more stringent threshold for dementia in HRSHCAP may miss people with mild Alzheimer's dementia, the Association believes that the larger CHAP estimates may be a more relevant estimate of the burden of clinical Alzheimer's dementia in the United States

Instead of genetic knockout, functional knockout of FoxO1 occurs naturally when -cells undergo LOsG/ROS stress