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By contrast, a 17-g increase in fat intake and a 50-g increase in carbohydrate intake was associated with a higher likelihood of wrinkles and skin atrophy.4 Discussion Demand for skin antiaging therapies is high and expected to increase.15 The use of oral supplements and systemic drugs to fight skin aging is an attractive option, as it would eliminate or reduce the need for topical treatments or invasive or minimally invasive procedures, which can be costly and are not without adverse effects

doi:10.3389/fphar.2020.564108 Mijit M, Caracciolo V, Melillo A, Amicarelli F, Giordano A

It has since reported phase 2 results with MET-097i and phase 1 data with MET-2331, and said in July it expects to generate data for the combination regimen late this year or early next