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Shaping the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseases

doi: 10.1186/s12876-016-0439-y 80 VitaRSaracenoGTrimarchiFBenvengaS

Although -oxidation is impaired in the setting of VPA toxicity, this metabolite has a prolonged elimination half-life and could be responsible for the prolonged coma that is sometimes observed despite the normalization in plasma VPA concentrations [17, 18]