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Retatrutide, a once-weekly injection, makes the body more efficient at regulating appetite, digestion, and energy expenditure by activating these three receptors: Glucose-dependent insulinotropic polypeptide (GIP) Glucagon-like peptide 1 (GLP-1) Glucagon (GCG) Phase-2 clinical trial data published in the New England Journal of Medicine showed that the drug is effective for weight loss