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A secondary effect of this stress is activation of Nrf2 and its target genes resulting in compensatory higher GSH levels and induction of antioxidant genes in the livers of these mice, which makes these livers more resistant to additional acute stress such as APAP toxicity [151]

Moreover, intellectual property issues, exclusivity rights, and high brand loyalty among customers toward branded drugs may hamper the adoption of biosimilars in some areas

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