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Experimental validation of broad-spectrum antivirals in viral infection assays The antiviral activity of the identified compounds phenformin, atpenin A5, SR13800, and scyllo-inositol was first tested in the lung-cancer cell line Calu-3 and the colon-cancer cell line CaCo-2 infected with SARS-CoV-2 (Fig

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showed that under combined hypoxia and TGF-1 stimulation, paricalcitol inhibits Smad2 phosphorylation, regulates hypoxia-inducible factor-1 (HIF-1) signaling, and reduces oxidative stress, thereby blocking the transition of pericytes into myofibroblasts (38)

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