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Int J Biol Sci 2016;12:56979

3 Many factors interfere with our natural production of GLP1, such as the things that lead to a leaky gut (compromised intestinal lining), such as dysbiosis, prescription drugs, anti-inflammatory OTC drugs, toxic exposure, etc

Without RCT data on semaglutide for the management of BAD, it is difficult to evaluate its safety and efficacy compared with other BAD therapeutics, but the abovementioned case underscores that newer, longer-acting, and more potent GLP-1RAs not necessarily provide better treatment results in BAD as compared with older, shorter-acting, and less potent GLP-1RAs such as liraglutide