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Elevated levels of pro-inflammatory cytokines such as IL-6 and TNF- are usually related to insulin resistance and alteration of insulin sensitivity in diabetic patients, while they can also be used as markers of renal damage in relation to diabetic nephropathy [131,132,133,134]

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When listed on the national health insurance, clear reimbursement criteria are established, making it easier for medical professionals to prescribe and oversee their use

After refining the data across all databases, 3,336 records were registered