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Clinical evidence from studies on diabetic CKD suggests that GLP-1 RAs not only improve glycemic control and reduce CV risk but also slow the progression of CKD through reduction in albuminuria, reduced systemic inflammation, enhanced endothelial function, and weight loss [37, 48]

By activating GIP receptors, tirzepatide enhances insulin secretion in a glucose-dependent manner, meaning insulin release occurs primarily when blood glucose levels are elevated, thereby reducing the risk of hypoglycemia

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