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doi: 10.3390/nu14173474 4

The difficulty in substantiating this link partly arises from the inherent complexity of interrogating these widely-distributed systems using pharmacological approaches, compounded by observations that native GLP-1 and pharmacokinetically-optimized therapeutic GLP-1 receptor agonists (GLP-1RAs) suppress eating via divergent signalling pathways 1622

Glucagon receptors: These target energy expenditure by increasing fat breakdown and promoting calorie-burning processes

688,691,802 We also discuss recent structural and biological work on metal transporters, some from the P-type ATPase superfamily, 803,804 as historical clients of the copper chaperones, 805,806 that are paired with an accessory protein(s) that may have metallochaperone-like features, or possess intrinsic metallochaperone activity itself