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The C-terminus of exendin-4, whilst not required for GLP-1R activation (Lee et al ., 2018), plays an important role in GLP-1R binding (Doyle et al ., 2003)
Effects of glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter-2 inhibitors, and their combination on endothelial glycocalyx, arterial function, and myocardial work index in patients with type 2 diabetes mellitus after 12-month treatment
doi: 10.2337/dc15-2479 76 AhrnBLeguizamo DimasAMiossecPSaubaduSAronsonR
Some doctors prescribed Ozempic or other GLP-1 drugs off-label for weight loss to non-diabetic patients or even pediatric patients, without FDA approval and without giving adequate warnings about the risks
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