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For instance, drugs like regorafenib impede cancer cell signaling by suppressing tyrosine kinase activity, while tamoxifen and others curb cancer cell growth and metabolism by inhibiting the mammalian target of rapamycin (mTOR) pathway [98, 99]

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report the cryo-electron microscopy structure of the activated glucagon-like peptide 1 receptor (GLP-1R) and provide a structural framework for understanding activation of class B G protein-coupled receptor (ref

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