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Se observ a los pacientes desde la primera prescripcin de un frmaco del estudio hasta la primera incidencia mutuamente excluyente (definida como el primer cdigo CIE-9 o CIE-10) de enfermedad biliar (incluidas colecistitis, colelitiasis y coledocolitiasis), pancreatitis (incluida pancreatitis por clculos biliares), obstruccin intestinal o gastroparesia (definida como el uso de un cdigo o un agente de promocin)

10.1056/nejmoa2032183

Deterioration of nuclear morphology and architecture: a hallmark of senescence and aging

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