(Source 1) The body makes glutathione from the amino acids cysteine, glycine, and glutamine
PubMed Europe PMC Scholia Crystal structures of gamma-glutamyltranspeptidase from Escherichia coli, a key enzyme in glutathione metabolism, and its reaction intermediate
Thus, selenium supplementation and GPx-1 overexpression were found to reduce DNA damage, as measured by micronuclei formation, and enhance cell survival in response to UV-irradiation (22), whereas knockdown of GPx-1 was found to increase UV-induced damage (21)
Moreover, administration of N-acetyl cysteine (NAC) or ascorbate, antioxidants that increase tissue glutathione levels, abolished ovariectomy-induced bone loss, while L-buthionine-(S,R)-sulphoximine (BSO), a specific inhibitor of glutathione synthesis, caused substantial bone loss