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We will continue to monitor claims and utilization patterns for C8001 and may reconsider the APC assignment in future notice-and-comment rulemaking

Calabro FJ, et al

Key Facts: Optimal window: 7-10 AM with breakfast aligns with natural NAD+ circadian peak Never dose after 4 PM high risk of sleep disruption and restlessness For doses above 300mg: split 60-70% morning, 30-40% by 2 PM Pre-workout dosing (30-60 min before) enhances training performance Consistency matters more than the exact hour pick a time and stick to it ## Getting NAD+ Timing Right Makes a Bigger Difference Than You Think We have seen patients take the exact same NAD+ product at different times of day and get meaningfully different results

The PI3K/Akt signaling pathway, which maintains protein balance, is inhibited under catabolic conditions such as sepsis, inflammation and immobilization, promoting UPS activation and protein degradation (68)