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Furthermore, with the increasing prominence of sarcopenic obesity, preserving lean mass in any weight loss strategy is important and this will be an area of increasing clinical and research interest

Notably, weight loss appeared to be exposure-dependent, with the cohort receiving the maximum dose of 2 mg/day for the entire study exhibiting the greatest weight loss ( Table 2 )

Consequently, regarding the formation of multidrug resistance in tumor cells, besides acting as a detoxification enzyme though excretion of drugs to decrease pharmacological efficacy, GST can also act as an MAPK-pathway inhibitor to improve tumor-cell survival