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Starting too aggressively can increase the likelihood of side effects, while increasing too slowly may delay results for patients who need stronger metabolic support

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The Wegovy labeling directs clinicians to "monitor renal function in patients reporting adverse reactions to WEGOVY that could lead to volume depletion, especially during dosage initiation and escalation." Volume depletion from persistent gastrointestinal losses can precipitate acute kidney injury, and that risk is higher in people with existing kidney impairment or on medications that affect renal perfusion

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