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Moreover, evidence supporting EGCGs neuroprotective effects via BBB-mediated anti-neuroinflammation and reduction of oxidative stress includes: (i) EGCG enhances dopamine neuron activity in the gut, decreases serotonin levels in the colon, and increases hippocampal 5-hydroxytryptamine levels by enhancing intestinal permeability (215217)

It can be caused by muscle or nerve problems which stop the intestinves from properly contracting and moving food along through the intestines

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Typically, candidates include adults with obesity or overweight conditions accompanied by related health issues such as high blood pressure, type 2 diabetes, or high cholesterol