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The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal

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Common gastrointestinal side effects include: Nausea (1222% of patients, dose-dependent) Diarrhea (1316% of patients) Vomiting (69% of patients) Constipation (67% of patients) Abdominal pain or discomfort (69% of patients) Decreased appetite (59% of patients) These effects are generally mild to moderate in severity and most pronounced during dose escalation