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The study also demonstrated encouraging safety and tolerability through 28 days of once-daily dosing, at doses up to and including 100 mg, with the majority of observed treatment emergent adverse events (TEAEs) reported as mild or moderate, and most reported as mild

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These data were summed up

Nature (2006) 439(7075):4023.10.1038/439402a 166 HaeuslerRACamastraSNannipieriMAstiarragaBCastro-PerezJXieDet alIncreased bile acid synthesis and impaired bile acid transport in human obesity