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Changes in hydration Many people on GLP-1 medications also notice: Reduced thirst Feeling full before drinking enough fluids Nausea that discourages drinking Less fluid intake, combined with slower digestion, often results in dehydration of the stool, further worsening constipation
Beyond pancreatic effects, tirzepatide acts on receptors in the central nervous system to reduce appetite and food intake, contributing to the weight loss observed in clinical trials
Statistical and reproducibility Statistical analysis was performed using GraphPad Prism (version 10.2.2)
[7] Whether this chloride flow is depolarizing (makes the voltage across the cell's membrane less negative), shunting (has no effect on the cell's membrane potential), or inhibitory/hyperpolarizing (makes the cell's membrane more negative) depends on the direction of the flow of chloride
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