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[12], who studied liraglutide induced acute biliary adverse events based on data derived from the LEADER trial and reported a significant increased risk of acute biliary complications in patients with liraglutide with (HR: 1.60

Interestingly, several studies have demonstrated that exendin-4 has neurotrophic and neuroprotective effects and that it enhances neurogenesis and neural proliferation (Li et al., 2009