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Genetic susceptibility and environmental exposures promote early activation of lymphocytes in the peripheral immune system ( + and CD8 + T cells, including T helper 1 (T H 1) and T H 17 subsets, together with B cells and innate immune cells, subsequently cross the blood-brain barrier (BBB) and infiltrate the CNS

The action of ten secreted aspartic proteases of pathogenic yeast Candida albicans on major human salivary antimicrobial peptide, histatin 5

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Individuals at the extremes of this range potentially make a total return-trip migration of more than 30,000 km, a distance comparable to that flown by the Arctic Tern ( Sterna paradisaea ) and other migratory champions