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From 2019 to 2024, among all adult patients with an overweight or obesity diagnosis, the percentage who were prescribed a GLP-1 drug but did not have bariatric surgery increased from 2.5 percent in 2019 to 11.2 percent in 2024, a relative increase of 339.5 percent

A study on mice with a triple knockout of CBS, CSE, and 3-MST supported this notion, revealing that supersulfides are still produced in the absence of these enzymes, further indicating the presence of compensatory or alternative mechanisms [40]