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A commenter noted that this measure would help address the under-prescription of evidence-based therapies and promote the appropriate use of combination or quadruple therapy, which includes beta-blocker therapy, in patients with HFrEF

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Wei Hu, Zhi Yang, Wenwen Yang, Mengzhen Han, Baoping Xu, Zihao Yu, Mingzhi Shen, Yang Yang, Roles of forkhead box O (FoxO) transcription factors in neurodegenerative diseases: A panoramic view, Progress in Neurobiology, Volume 181, 2019, 101645, ISSN 0301-0082,

Significant mood changes Mood changes and worsening depression, or any thoughts of self-harm that develop or worsen after starting a GLP-1 medication should be discussed with a doctor promptly