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These medications are contraindicated in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

doi: 10.1159/000525582 91 ZhangCYangMEricssonAC

Fatigue on tirzepatide and semaglutide-related fatigue can create a cycle where poor sleep worsens digestive symptoms, digestive discomfort disrupts sleep further, and the combined effect makes side effects harder to tolerate

Approved by the FDA in 2005, long before semaglutide, it is a mimic of a 39-amino acid peptide called exendin-4, which was originally isolated from a type of lizard known as the Gila monster