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Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity
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This process triggers a potent inflammatory response, characterized by the upregulation of pro-inflammatory cytokinesincluding IL-1 and interferon- (IFN-)and the concomitant downregulation of tight junction proteins, thereby compromising mucosal barrier integrity 76
However, other factors may be involved, including accumulation of lactate, pyruvate, glutamine and free glucose, and depletion of glycogen, ketone bodies and glutamate
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