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ZSF1 rats are the result of cross breeding female Zucker diabetes fatty (ZDF) rats with male spontaneously hypertensive heart failure (SHHF) rats

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ABCG2 dysfunction caused by common variants will significantly increase the risk of hyperuricaemia, and the reduction of extra renal urate excretion through dysfunctional ABCG2 is a common mechanism of hyperuricaemia (Ichida et al., 2012)

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