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GLP-1 receptor agonist treatment in subgroups defined by cardiovascular and kidney disease is important for informing clinical decision-making based on clinical impact. In a comparative effectiveness study, the researchers reviewed data from adults with type 2 diabetes in Denmark who were treated with an SGLT2 inhibitor, including empagliflozin (Jardiance, Boehringer Ingelheim) or dapagliflozin (Farxiga, AstraZeneca) or a GLP-1 receptor agonist, including liraglutide (Victoza/Saxenda, Novo Nordisk), semaglutide (Ozempic/Wegovy, Novo Nordisk) or dulaglutide (Trulicity, Eli Lilly)

Sequential or alternating dose regimes can optimize metabolic benefits by leveraging acute NAD+ increases from NMN during high-demand periods and stabilizing metabolic optimization with NNMT inhibition

doi: 10.1016/j.peptides.2019.170224 37 McIntoshCHWidenmaierSKimS

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