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Deviations in pH can accelerate chemical degradation pathways including deamidation (where certain amino acid residues chemically change), oxidation (where the peptide reacts with oxygen), and hydrolysis (where water molecules break peptide bonds)

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Patients who already have coverage should not switch to the Bridge, as doing so could disrupt their existing coverage structure

Few articles have additionally recommended the consideration of rapid sequence induction, stating that there should be a low threshold for this method of securing the airway, especially in the setting of uncertainty regarding gastric contents (Joshi 2024