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For those with fluid restrictions (e.g., heart failure, kidney disease), fluid intake recommendations should be discussed with a healthcare professional

When this process is disrupted, bilirubin can accumulate in the bloodstream, leading to elevated serum levels a condition that may present as jaundice, fatigue, or dark urine

In addition, the high uptake of proline and glucose by vascular endothelium and medial biomass can promote extracellular matrix synthesis and vascular wall thickening (Wertheim et al., 2023)

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