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The top dose produced 20.9% average weight loss over 72 weeks and 20.2% in a direct comparison with semaglutides 13.7%. Its second receptor, GIP, separates tirzepatide from approved single-receptor GLP-1 drugs and helps explain the larger population-level weight loss. That 20.9% came from participants averaging about 105 kg at a BMI of 38, most of whom were sedentary
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[7] Klicek, R., Sever, M., Radic, B., & Sikiric, P
Glucagon promotes hepatic fat metabolism, suggesting potential utility in research related to non-alcoholic fatty liver disease (NAFLD)
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