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Counteracting oxidative stress by Nrf2 upregulation is effective for treating neurological disorders [24, 99]

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In order to prove the essential role of m6A in regulating SLC7A11, a luciferase reporter, an inserted mutant (Mut), and a wild-type (WT) SLC7A113UTR sequence equivalent to its mutating putative m6A sites were designed ( Figure 5F )