Injections require more setup: sterile supplies, proper injection technique, and site rotation to avoid irritation
Causes The primary cause of melanosis coli is the chronic use of certain types of laxatives, particularly those containing anthraquinones, which are natural compounds found in certain plants
*Methylcobalamin (Vitamin B12) is also indicated in those with pernicious anemia, diabetes, neuropathy, heart disease, circadian rhythm sleep disorders, memory loss, depression, fatigue, AIDS, inflammatory bowel disease (IBD), Lyme disease, osteoporosis, tendonitis, psychiatric disorders, Alzheimers disease, liver and kidney disease, and asthma
For patients with severe renal impairment (eGFR less than 30 mL/min/1.73 m2) or with end-stage renal disease (ESRD) requiring hemodialysis or peritoneal dialysis, the dose of JANUVIA is 25 mg once daily