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Research was performed according to the principles of the Declaration of Helsinki of 2013

Severe Brain Fog and Mental Fatigue: By suppressing microglial activation and reducing the release of inflammatory cytokines (like IL-6 and TNF-) in the brain, Pycnogenol helps clear the inflammatory "static" that disrupts cognitive processing and executive function

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These mechanisms manifest as several distinct but interconnected pathophysiological features that contribute to the clinical presentations of the disease