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It was once seen as medicinal but later as harmful

In the early stage of the disease, mitophagy mostly acts as an adaptive compensatory mechanism to play a protective role, while with the progression of the disease to the late stage, the regulatory mechanism of mitophagy is disrupted, often showing a state of excessive activation, thereby aggravating tissue damage

Various factors, including stress, poor nutrition, and exposure to environmental toxins, can impact glutathione levels in the cells

There is clear evidence to illuminate that defective Ca 2+ channel function can lead to ASD with penetrance as high as 60-80%