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An enzyme called DPP-4 breaks it down quickly, which is why the bodys own supply has limited reach in any tissue

Indeed, nNOS induction has been noted with a 6 day sleep deprivation protocol in mice (Chittora et al., 2022), which may well serve to promote rebound sleep and in turn lower nitrogen load

7 These reactive molecules are mainly produced by the mitochondria through oxidative phosphorylation, 15 which also produce other intracellular ROS such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, the main source of ROS in phagocytes, for example

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