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Advances in metabolomics and nutrigenomics suggest that specific patient subpopulations may realize the greatest benefit, indicating a move away from generalized supplementation toward a more targeted adjunctive therapy integrated with evidence-based cardiovascular care (Minihane et al., 2015)

MnSOD is elevated in primary tumors with lymph node metastases while comparing gastric cancer patients with and without metastasis, indicating that MnSOD and ROS are involved in metastasis (164)