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3.3.4 AIM2 inflammasome pathway Absent in melanoma-2 (AIM2) inflammasome is a member of the innate immune sensor, which can detect double-stranded DNA (dsDNA), including mtDNA, in the cytoplasm independent of sequence

Most of the studies are still mainly focused on tumor cells ( At present, the rapidly rising prevalence of obesity has become a global problem that needs to be solved

Receptor mechanism and potency

Although IFN- augments the anti-tumor efficacy of CD8 + T cells, the tumor immune microenvironment (TIME) considerably affects this mechanism, possibly restricting ferroptosis in immunologically inert malignancies (57, 58)