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The following are key considerations when counseling patients on GLP-1s: 1) Stop the medication in advance

Here we studied the effects of semaglutide on the circulating proteome using baseline and end-of-treatment serum samples from two phase 3 trials in participants with overweight or obesity, with or without diabetes: STEP 1 ( n = 1,311) and STEP 2 ( n = 645)

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This observation provided the rationale for the development of pharmacological GLP1R agonists, which are now widely used in the treatment of T2D (Ling et al., 2019)