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Gradually increase fiber and fluids to normalize stool consistency and reduce local irritation

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271 ci-Ins2 silencing in pancreatic islets leads to decreased expression of several genes important for insulin secretion ( Rapgef4 , Pld1 , Pclo , and Cacna1c ) by interacting with the TAR DNA-binding protein 43 (TDP43), thereby contributing to -cell dysfunction during diabetes

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1996 Sep;36(18):3003-9

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