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DPP4i have no intrinsic glucose-lowering activity, so their efficacy as anti-diabetic agents is related directly to their ability to inhibit DPP4 activity and is mediated through the effects of the substrates they protect

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Dry mouth and nausea Nausea reduces the desire to eat and drink, worsening dehydration and dry mouth

Orforglipron is a once-daily tablet designed to act as an oral GLP-1 receptor agonist