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It was found that the dosage of VPA was negatively correlated with the levels of total carnitine and free carnitine, suggesting that sodium valproate had a negative effect on the bioavailability and metabolism of carnitine (, )

[2] [3] NAD+ is continuously recycled within cells as it is interconverted to and from its various forms through salvage pathways

Thus, glutamine metabolism serves as a metabolic rheostat for ferroptosis sensitivity by coordinately regulating iron homeostasis and oxidative stress

Towards this end, we generated a Dox-inducible overexpression construct driving the expression of RRM1 and RRM2 joined with a self-cleaving P2A cassette (HT-1080 RNR Dox )