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if 1% or more of body weight has not been lost, it is unlikely the patient will achieve and sustain clinically meaningful weight loss with continued treatment and this drug should be discontinued
A distinguishing feature of these nanoparticles is that they specifically target cancer cells while preserving surrounding tissue from radiation-induced damage and oxidative stress, functioning as both radio-protecting and radio-sensitizing agents at the same time [395]
As a result, drugs that are administered systemically through vasculature can have challenges in crossing the BBB
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