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Interestingly, decreased availability of eNOS substrates, L-arginine or tetrahydrobiopterin (BH 4 ), can promote enzymatic uncoupling of eNOS such that it generates superoxide instead of nitric oxide [54]

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Nanayakkara G, Alasmari A, Mouli S, Eldoumani H, Quindry J, McGinnis G, et al

For instance, a minimum intracellular selenium status (in terms of the concentration of hydrogen selenide) is required for the translation of all seleno-GPxs