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Despite these being isolates from patients, only a few strains caused cytotoxicity, reflected in release of the cytoplasmic enzyme lactate dehydrogenase (LDH), of A-431 vulvar epithelial cells in vitro (Fig

Although the study did not distinguish the efficacy among different heterozygous LMP variants, it confirmed that heterozygous mutations in the LMP pathway (including MC4R ) are associated with compromised long-term surgical outcomes, consistent with the findings in heterozygous MC4R P/LP variant carriers